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mavorixafor will boost the amount or outcome of codeine by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. Mavorixafor (a solid CYP2D6 inhibitor) is contraindicated with prescription drugs that are really depending on CYP2D6 for clearance.benzhydrocodone/acetaminophen and codeine both of those improve sedation. Avoid or Use Alternate D